A basic picture of nuclear excited states can be described by one-particle one-hole (1p1h) excitation. Experimental data of inelastic scatterings of nucleon-nucleus reaction are reasonably reproduced theoretically in this picture. However, it is known that higher-order configurations are important for a better understanding of the excited states. This may apply to the inelastic scattering. However, the relation between higher-order configuration and inelastic scattering is still not clear. To clarify the relation between higher-order configuration and inelastic scattering, we consider two-particle two-hole (2p2h) excitation of target nuclei and pay attention to the angular differential cross sections. The 2p2h stats of target nuclei are calculated by Second RPA, and the reaction process is calculated by DWBA. As reaction channels, inelastic scattering and (p,n) reaction are chosen. Our approach reproduces experimental data reasonably. However, it turned out that the diffraction patterns of the angular differential cross section considering 2p2h excitation were not significantly different from those considering 1p1h excitation although the absolute values were smaller than 1p1h calculation if the same nucleon-nucleon force is used for 1p1h and 2p2h calculations. This indicates that the effect of 2p2h contribution cannot be seen in the inelastic channels. We discuss it in more detail from the nuclear structural point of view.